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Creatine is renowned for enhancing strength, but its benefits extend far beyond muscle power. In this episode, Dr. Darren Candow, a leading researcher with over 140 peer-reviewed publications, explores creatine’s diverse physiological impacts, from bolstering cognitive resilience under stress to mitigating symptoms of depression and protecting against cognitive decline caused by sleep deprivation. He explains why the conventional dosage of 5 grams per day might be insufficient, and how higher doses (10–25 grams) could unlock additional therapeutic effects.

Timestamps:

(00:00) Introduction
(04:34) What makes creatine effective for exercise performance?
(08:01) The loss of explosive power with aging
(09:36) How creatine speeds up recovery between sets
(12:13) Two ways creatine boosts muscle strength
(14:12) Why creatine might not speed typical weight-training recovery
(16:38) Anti-catabolic effects
(17:16) Why do men and women respond differently?
(18:50) Dietary creatine vs. supplementation
(19:36) Is creatine supplementation necessary—or optional?
(21:05) Why plant-based may benefit most
(22:15) Should creatine dosage change with age?
(23:01) Loading vs. daily dosing
(25:57) Why 5 grams might not be enough—other tissues
(27:48) Can creatine prevent bone loss—even without weight training?
(28:10) How creatine supports osteoblast activity
(29:51) Preventing hip fractures with creatine
(32:33) Creatine vs. bisphosphonates
(36:21) Why creatine isn’t just for weightlifters
(38:52) Why stressed brains benefit most
(40:57) Why brain aging accelerates demand
(43:54) Why 10g per day might be the optimal dose
(45:45) Why creatine counteracts sleep deprivation
(48:53) Before vs. after concussion
(51:17) Should dosage be adjusted by weight?
(52:39) Does creatine improve sleep on training days?
(55:34) Creatine for Alzheimer’s and Parkinson’s—does the science hold up?
(57:08) Can creatine help with depression and anxiety?
(1:00:24) The role of creatine and glutamine in preventing respiratory illness
(1:02:40) Why creatine may enhance endothelial health and circulation
(1:04:04) Creatine’s role in cardiometabolic health
(1:05:45) When does loading actually make sense?
(1:06:51) Creatine’s dual role—preserving muscle and enhancing recovery after injury
(1:09:46) Is creatine effective without exercise?
(1:12:01) Why creatine might improve male fertility
(1:13:57) Is it safe for children?
(1:17:21) Creatine supplementation during pregnancy
(1:18:54) Could creatine boost motor skills in kids?
(1:19:34) Creatine monohydrate vs. the rest
(1:24:15) How to avoid digestive issues with creatine supplementation
(1:26:56) Does timing matter—and should you cycle it?
(1:28:32) Should you take creatine every day—or only workout days?
(1:29:17) Why caffeine might blunt the effects
(1:32:21) Does creatine increase body fat—or is that a myth?
(1:33:08) Preventing cramps (the hydration myth)
(1:34:33) Understanding the creatinine confusion—why creatine won’t damage your kidneys
(1:36:59) Why creatine is linked (wrongly?) to baldness
(1:40:22) Debunking myths—sleep, cancer, urination
(1:43:39) How creatine affects homocysteine levels
(1:46:32) Creatine and protein—the ideal post-workout pair?
(1:49:26) How to pick the best creatine supplement
(1:51:46) What to know about micronized creatine

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#100 The Optimal Creatine Protocol for Strength, Brain, and Longevity | Darren Candow, PhD

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